FDA & EMA
In 2010 the International Transporter Consortium (ITC) published a review titled Membrane transporters in drug development in which is defined which transporters are clinically relevant and have to be investigated under drug development. In the same year the EMA published a guideline for investigation of clinically relevant transporters. These relevant transporters are listed in the following table.
Transporter |
ITC | EMA |
| OCT1 | + | |
| OCT2 | + | + |
| OAT1 | + | + |
| OAT3 | + | + |
| OATP1B1 | + | + |
| OATP1B3 | + | + |
| MDR1 (P-gp) | + | + |
| BCRP | + | + |
| BSEP | + |
