PortaCellTec biosciences GmbH

Summary

Gene  name Protein  name Expression / Localization Substrates endogenous Substrates exogenous Transport Type
SLC10A1 hNTCP liver, pancreas bile acid, estrone sulfate, DHEA-S BSP cotransporter
SLC10A2 hASBT kidney, ileum,bile, small intestine bile acids, taurocholate dimeric bile acid analogues, benzothiazepine derivates cotransporter
SLC10A6 hSOAT1 testis, placenta, pancreas, heart, lung, liver, spleen, small intestine, colon estrone sulfate,
DHEA­-S, PREG-S, bile acid sulfate		   cotransporter
SLC13A3 hNaDC-3 kidney, liver, pancreas, brain, placenta succinate, citrate, α-keto-glutarate, L-glutamate   cotransporter
SLC22A1 hOCT1 liver, kidney organic cations acyclovir, amantadine,
desipramine, ganciclovir, metformin		 facilitated transporter
SLC22A2 hOCT2 kidney, brain organic cations amantadine, cimetidine, memantine facilitated transporter
SLC22A3 hOCT3 kidney, liver, skeletal muscle, placenta, heart, lung, brain organic cations cimetidine facilitated transporter
SLC22A6 hOAT1 kidney, placenta, brain organic anions penicillin, torasemid, acyclovir, methotrexate, zidovudine, PAH exchanger
SLC22A7 hOAT2 liver, kidney

cGMP, GMP, 2-deoxyguanosine

 bumetanide, cyclothiazide, methotrexate, diclofenac, indomethacin,mefenamate  
SLC22A8 hOAT3 kidney, liver, brain, skeletal muscle, developing bone organic anions, estrone sulfate, DHEA-S cimetidine, methotrexate, zidovudine, PAH exchanger
SLC22A11 hOAT4 kidney,  placenta organic anions, estrone sulfate, DHEA-S ochratoxin asymmetric exchanger
SLC47A1 MATE-1 liver, kidney organic cations TEA, MPP exchanger
SLCO1A2 hOATP1A2 brain, kidney, liver estrone sulfate, DHEA-S fexofenadine, oubain, tauroursodeoxycholate  
SLCO1B1 hOATP1B1 liver bile salts, taurocholate, estrone sulfate BSP, benzylpenicillin, pravastatin, rosuvastatin, rifampicin, methotrexate  
SLCO1B3 hOATP1B3 liver bile salts, taurocholate BSP, fluvastatin, pravastatin, pitavastatin, methotrexan  
SLCO2B1 hOATP2B1 liver, kidney, intestine, brain, placenta, heart estrone sulfate, DHEA-S, PREG-S pravastatin, fexofenadine, atorvastine exchanger

BSP = sulfobromophthalein
DHEA-S = dehydroepiandrosterone-sulfate
MPP = 1-methyl-4-phenylpyridinium
PAH = para-aminohippuric acid
PREG-S = pregnenolone sulfate
TEA = tetraethylammonium

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2012