Transporter

PortaCellTec biosciences offers transporter assays listed in the following table. All transporters are stably expressed in HEK-293 cells (human embryonic kidney cells).

 

Transporter gene  name	Transporter  protein name	Reference substrate	Reference Inhibitors
SLC10A1	hNTCP	estrone sulfate	cyclosporine, furosemid
SLC10A2	hASBT	DHEA-S	BSP, cyclosporin
SLC10A6	hSOAT1	estrone sulfate
SLC13A3	hNADC-3	succinate	dimethylsuccinate
SLC22A1	hOCT1	MPP	quinine, quinidine
SLC22A2	hOCT2	MPP	tetrabutylammonium, cimetidine
SLC22A3	hOCT3	MPP	corticosterone, quinidine
SLC22A6	hOAT1	PAH	probenecid, glibenclamide
SLC22A7	hOAT2	cGMP	indomethacin, bumetanide
SLC22A8	hOAT3	estrone sulfate	probenecid, indomethacin
SLC22A11	hOAT4	estrone sulfate	probenecid, BSP
SLC47A1	hMATE-1	MPP	quinidine, cimetidine
SLCO1A2	hOATP1A2	BSP, DHEA-S	rifampicin, ritonavir
SLCO1B1	hOATP1B1	estrone sulfate	rifampicin, ritonavir
SLCO1B3	hOATP1B3	BSP	rifampicin, ritonavir
SLCO2B1	hOATP2B1	estrone sulfate	rifampicin, cyclosporin

BSP                sulfobromophthalein
DHEA-S         dehydroepiandrosterone-sulfate
MPP               1-methyl-4-phenylpyridinium
PAH                para-aminohippuric acid

 

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Transporter

FDA & EMA